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Skeletal, or voluntary, muscle constitutes the principal organ of locomotion as well as a vast metabolic reservoir Disposed in more than 600 separate muscles, this tissue makes up as much as 40 percent of the weight of adult human beings An intricacy of structure and function undoubtedly accounts for its diverse susceptibility to disease, for which reason the main anatomic and physiologic facts are provided as an introduction to the following several chapters on muscle disease For the purposes of exposition, diseases of the neuromuscular junction are presented in the chapters that follow (Chap 53) A single muscle is composed of thousands of muscle bers that extend for variable distances along its longitudinal axis Each ber is a relatively large and complex multinucleated cell varying in length from a few millimeters to several centimeters (34 cm in the human sartorius muscle) and in diameter from 10 to 100 m.

FIGURE 1-4

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Some bers span the entire length of the muscle; others are joined end to end by connective tissue Each muscle ber is enveloped by an inner plasma membrane (the sarcolemma) and an outer basement membrane The multiple nuclei of each ber (cell), which are oriented parallel to its longitudinal axis and may number in the thousands, lie beneath the plasma membrane (sarcolemma) hence they are termed subsarcolemmal or just sarcolemmal nuclei The cytoplasm (sarcoplasm) of the cell is abundant and contains myo brils, various organelles such as mitochondria and ribosomes; each myo bril is enveloped in a membranous net, the sarcoplasmic reticulum (SR; Fig 45-2) Extensions of the plasma membrane into the ber form the transverse tubular system (T tubules), which are extracellular channels of communication with the intracellular sarcoplasmic reticulum The SR and T tubules are anatomically independent but functionally related membrane systems.

FIGURE 8-7

How is normocalcemia related to bone development and bone matrix you might well ask at this time. The answer is provided by a close look at Figure 13.7. During the development of a long bone, such as the femur ( thigh bone), the process essentially begins with a cartilage model a miniature version of the bone that is composed of cartilage, rather than bone tissue. Being soft and rubbery, cartilage is more suitable for life within the mother s uterus (womb). As development progresses, however, blood vessels break into the cartilage model and bring osteoblasts (AHS-tee-oh-blasts) along with them. Osteoblasts are literally bone (oste) formers (-blasts). The osteoblasts are large, spider-shaped cells that produce bone collagen bers. After these tough collagen bers are laid down, the osteoblasts then extract Ca ions, phosphorus, and other chemicals from the bloodstream. Ossi cation (ah-sih- h-KAY-shun), the process of bone formation, then begins. During ossi cation, the osteoblasts supervise the depositing of sharp, needle-shaped crystals onto the surfaces of the bone collagen bers. These sharp crystals are composed of calcium phosphate (FAHS-fate), as well

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9t 3 t 4 The distance between home and school is 10t 10 3 15 71 4 2 2 miles. 2. Let t represent the number of hours Toni spent driving to work. Then t 18 represents the number of hours driving home. The dis60 tance from home to work is given by d 30t, and the distance from work to home is given by d 45 t 18 . 60 18 30t 45 t 60 3 30t 45 t 10 30t 45t 30t 45t 45t 45t 135 10 27 2

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