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Reserved for future use 9x unprotected UID allocations Reserved for future use For development use Legacy UID compatibility

0 35 55 86 99 37 62

45 50 76 96 99 62 77

b) Select the following check boxes (Figure 13-13):

59 63 91 99 86 92

AChR, antiacetylcholine receptor; SFEMG, single ber electromyography With permission from Dumitru D, Amato AA Neuromuscular junction disorders In: Electrodiagnostic Medicine, 2nd edn, 25 Philadelphia: Hanley & Belfus, 2002, p 1165

3 Click on the My Symbian Signed tab along the top 4 Click on UIDs, and then click Request in the left sidebar 5 Select either Protected Range or Unprotected Range 6 Enter the required information and click Submit

c) Look in the local hard drive (on most systems this will be the C:\ drive) where your operating system is located and search for the following les Make notes of their absolute paths:

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The evaluation of a patient with a suspected CMS can be a specialized undertaking that exceeds the capabilities of most institutions AChR antibodies, anti-voltage-gated calcium channel antibodies, and potentially other serological tests to address and exclude autoimmune DNMT should be considered Demonstrating a decremental response to slow repetitive stimulation will support the existence of a DNMT It will not, however, distinguish CMS from other NMT disorders, nor will the absence of a decrement exclude a CMS from consideration Identi cation of an afterdischarge(s) as described in 2 (Fig 23 4) is not speci c for AChE de ciency or the slow channel syndrome but is very suggestive in the appropriate clinical context MUAP variability may be dif cult to demonstrate in an uncooperative child and has the same limitations as a slow repetitive stimulation SFEMG, a sensitive but nonspeci c test, is usually reserved for patients in whom a decremental response cannot be demonstrated In children, SFEMG is usually performed by the stimulated rather than the voluntary technique Ultimately, the identi cation of the existence and likely subtype of CMS may depend on a very specialized testing, which includes in vitro electrophysiological analysis such as patch-clamp experiments on single AChR channels, ultrastructural and immunocytochemical synaptic imaging, and potential genetic analysis in research laboratories

onds, are small, and can be easily overlooked These afterdischarges may decrement or disappear with repetitive stimulation delivered at the rates of 02 and 2 Hz A decremental response may occur at both slow (eg, 2 Hz) and fast (eg, 40 Hz) rates of stimulation The administration of edrophonium does not alter the decrement Routine needle electromyographic examination demonstrates MUAP instability Abnormal spontaneous activity is absent

Routine conduction studies are normal322 327 Repetitive stimulation at 2 3 Hz reveals a decremental response There is no abnormal spontaneous activity SFEMG analysis demonstrates increased jitter and blocking

Symbian applications are distributed in SIS files an archive-like file format that includes the files for installation as well as a manifest-like file that specifies where they should be placed on the filesystem These packages support a basic level of flow control to allow developers to create a single installer that contains the binaries for different Symbian versions/platforms All SIS files consist of a header and a sequence of word-aligned Type-Length-Value (TLV) SISFields This allows for a parser to efficiently skip over unnecessary parts of the file without wasting space by loading the entirety into the limited memory available The basic layout can be seen in Figure 7-6 The header consists of three package UID (pUID) values and a UID checksum However, these should not be confused with the UID values within the header of an executable image The first pUID identifies the package as an SIS file and will always be set to 0x10201A7A The second pUID is reserved for future use and is generally set to 0x00000000 The third pUID uniquely identifies the installation package, allowing the installer to identify package upgrades in the future Attempting to install another SIS file with the same pUID will fail The rules regarding the selection of an appropriate pUID are identical to those surrounding the UID3 values found within executables It is recommended to use the UID3 of the principal application within the installation script as the pUID

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